Hormones and Mitochondria


Health First Pharmacy in Windsor

  • Sonoma County's Best Compounding Pharmacy

Dr Mark Burger a local expert pharmacist and owner of Health First Pharmacy, is respected the world around for his contributions to the field of pharmacy as well as the field of clinical medicine. The breadth of his experiences, spanning more than 30 years, give him unique insights into the world of medications and how they interact within the human body. Here is what he shared about Mitochondria:


"I’ve been reading a lot about MITOCHONDRIA recently. I think it’s the Go To for overall health and longevity (along with hormone balance).

Turns out, unbeknownst to me, that the MITOCHONDRIA are Ground Zero for hormone biosynthesis and hormone health. Who knew?

When your mitochondria are damaged by oxidative stress (that’s why you produce less Testosterone as you age … d’oh!) both E and T protect the mitochondria from age damage (It’s a 2-way street, evidently). Your BRAIN MITOCHONDRIA are affected by hormones. You gotta have THYROID hormone for your mitochondria to work properly.

Post-menopausal OBESITY and INSULIN RESISTANCE might be due to skeletal muscle mitochondrial DYSFUNCTION caused by a drop in ESTROGEN LEVELS!

[yeah. you thought estrogen was making you fat, right?]

Depressed CARDIAC MITOCHONDRIAL ESTROGENS corresponds to a decrease in cardiac fxn after trauma or MI or hemorrhage [ergo: Don’t stop HRT in the CCU!]

Remember Dr. Pamela Wharton Smith telling us she mandates her HRT patients get a bottle of B-vitamins with every refill of HRT? Well, we should be selling a bottle of CoQ-10 with every HRT script, too IMHO!! [50-100 mg PO BID w/food]"


Dr Burger, the owner of "Health First Pharmacy" in Windsor offers consultations, and can be reached by calling: 707-837-7948

References:

[WHAT ASPECTS THE PAPERS ADDRESS]

  1. Ramalho-Santos J and Amaral S. Mol Cell Endocrinol. 2013 Oct 15;379(1-2):74-84. [CYP 450 CONVERSION OF CHOLESTEROL > PREGNENOLONE]
  1. Strushkevich N, et al. Proc Natl Acad Sci USA. 2011 Jun 21;108(25):10139-43. [CYP 450 CONVERSION OF CHOLESTEROL > PREGNENOLONE]

  2. Le B, et al. Andrology. 2014 May 12. [Epub ahead of print.] [INCREASED LEYDIG CELL PRODUCTION OF TESTOSTERONE]

  3. Psarra AG, et al. IUBMB Life. April 2008. 60(4):210-23. [RECEPTORS FOR ESTROGEN, TESTOSTERONE, THYROID ON MITOCHOND]

  4. WickramasekeraNT and Das GM. Mitochondrion. 2014 May;16C:26-37. [RECEPTORS FOR ESTROGEN, TESTOSTERONE, THYROID ON MITOCHOND]

  5. Vasconsuelo A, et al. Steroids. 2011 Nov;76(12):1223-31.Gigli I and Bussmann LE. Life Sciences. 2001;68(13):1505-14. [E & T PROTECTING MITOCHONDRIA]

  6. Gigli I and Bussmann LE. Life Sciences. 2001;68(13):1505-14. [CONTROL OF KREBS CYCLE RESPIRATION BY ESTROGENS]

  7. Klinge CM. Journal of Cellular Biochemistry. 2008;105(6):1342-51. [CONTROL OF KREBS CYCLE RESPIRATION BY ESTROGENS]

  8. Kulinsky VI and LS Kolesnichenko. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. June 2007;1(2):95-113. [CONTROL OF KREBS CYCLE RESPIRATION BY ESTROGENS]

  9. Sharpe MA, et al. J Toxicol. 2013;2013:159810. [CONTROL OF KREBS CYCLE RESPIRATION BY TESTOSTERONE]

  10. Vasconsuelo A, et al. Ageing Res Rev. 2013 Sep;12(4):907-17. [PROTECTION OF MITOCHONDRIA FROM AGIN BY E AND T]

  11. Amaral S, et al. Front Biosci (Schol Ed). 2013 Jan 1;5:181-97. [Aging/Infertility]

  12. Amaral S and Ramalho-Santos J. Curr Aging Sci. 2009 Dec;2(3):165-73. [Aging/Infertility]

  13. Irwin RW, et al. Endocrinology. 2008 Jun;149(6):3167-75. [EFFECT ON BRAIN MITOCHONDRIAL EFFICIENCY]

  14. Hara Y, et al. Proc Natl Acad Sci USA. 2014 Jan 7;111(1):486-91. [ESTRADIOL / WORKING MEMORY / FLAWED, DONUT-SHAPED MITOCHONDRIA]

  15. Federica Cioffia, et al. Molecular and Cellular Endocrinology. 15 October 2013;379(1-2):51-61. [THYROID (T3) REGULATION OF MITOCHONDRIAL MASS/BIOGENESIS]

  16. Harper ME and Seifert EL. Thyroid. 2008 Feb;18(2):145-56. [THYROID (T3) REGULATION OF MITOCHONDRIAL FXN]

  17. Soboll S. Biochim Biophys Acta. 1993;1144:1-16. [THYROID (T3) REGULATION OF MITOCHONDRIAL FXN]

  18. Golgi F, et al. J Mol Endocrinol. 1994;13:275-82. [THYROID (T3) REGULATION OF MITOCHONDRIAL FXN]

  19. Hsieh YC, et al. FASEB J. 2006;20:1109-17. [Estradiol/Cardiac Mitochondrial Levels]

  20. LaBarge S, et al. FASEB J. 2014 Mar;28(3):1082-97.

  21. Cavalcanti-de-Albuquerque JP, et al. J Appl Physiol (1985). 2014 Apr 1;116(7):779-89. [OBESITY / INSULIN RESISTANCE]

  22. George A and Henkel R. Andrologia. 2014 Jan 6. [Epub ahead of print.] [TONGAT ALI TO INCREASE TESTOSTERONE / MAY PREVENT PROSTATE CA]

  23. Licznerska BE, et al. Eur J Nutr. 2013 Aug;52(5):1483-92. [I-3-C / DIM and CANCER PREVENTION]

  24. Sandhir R, et al. Neurochem Int. 2014 Apr 26;74C:16-23. [STESS / MITOCHONDRIAL DAMAGE / COQ-10]

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